RNAiDB Tree View

Gene: Y37H2C.3

Y37H2C.3	SMap	S_parent	Sequence	SUPERLINK_CB_V
	Chromosome	V
	Identity	Version	1
		Name (5)
		Species	Caenorhabditis elegans
		History	Version_change	1	26 May 2004 16:54:54	WBPerson1971	Event	Imported	Initial conversion from CDS class of WS125
		Status	Live
	Gene_info	Structured_description	Provisional_description	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.	Paper_evidence	WBPaper00012854
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				The F-box motif consists of roughly 50 amino acids.
				There are at least 11 F-box genes encoded by the genome of budding yeast, 22 in Drosophila, and 38 in human beings; but a striking 326 F-box genes are predicted to exist in C. elegans, comprising 1.6% of the protein-coding genome.
				This disproportionate number of F-box genes is paralleled by the number of Skp-1 homologs (which are potential F-box ligands) encoded in these genomes: while there are 2, 7, and 1 Skp-1 related genes predicted in the genomes of Dictyostelium discoideum, Drosophila, and Homo sapiens, there are 17 Skp-1 homologs in C. elegans.
				F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, Skp-1, Cullin, and an F-box protein), in which they bind substrates for ubiquitination (and, thus, subsequent proteolysis); in SCF complexes, the F-box motif links its protein to other SCF components by binding Skp-1 protein.
				However, F-box proteins are by no means confined solely to SCF complexes: for instance, yeast Skp-1 can bind non-SCF F-box proteins to perform cellular functions completely distinct from protein degradation, such as kinetochore function (binding the F-box protein Ctf13p) or SNARE recycling (by binding the F-box protein Rcy1p), as well as yet other F-box proteins of unknown function (Yjl149 and Yml088).
			Concise_description	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
	Molecular_info (4)
	Experimental_info	RNAi_result	Cenix:50-d8
			JA:Y37H2C.3
		WB_RNAi_result	JA:Y37H2C.3
			MV_SV:mv_Y37H2C.3
			Cenix:50-d8
	Method	Gene