Y39E4A.3 | SMap | S_parent | Sequence | Y39E4A
|
| Chromosome | III |
|
Identity
| Version | 1 |
| |
Name (5)
|
| | Species | Caenorhabditis elegans
|
| | History | Version_change | 1 | 26 May 2004 16:54:54 | WBPerson1971
| Event | Imported | Initial conversion from CDS class of WS125 |
| | Status | Live |
|
Gene_info
| Allele | snp_Y39E4[13]
|
| |
GO_term
| GO:0016624
| IEA
| Inferred_automatically |
| | | GO:0008152
| IEA
| Inferred_automatically |
| |
Structured_description
|
Provisional_description
| Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial. | Paper_evidence | WBPaper00004424
|
| | | | | Person_evidence | WBPerson567
|
| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial. |
| | | | Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile. |
| | | | For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles. |
| | | | By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein. |
| | | | The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors. |
| | | Concise_description | Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial. |
|
Molecular_info (5)
|
|
Experimental_info
|
RNAi_result
| Cenix:321-a9
|
| | | JA:Y39E4A.3
|
| |
WB_RNAi_result (5)
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| |
Y2H_bait
| Y2H001944
|
| | | Y2H008556
|
| | | Y2H008557
|
| Method | Gene
|