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Gene: Y39E4A.3   

Y39E4A.3SMapS_parentSequenceY39E4A
ChromosomeIII
Identity (5)
Gene_info Allelesnp_Y39E4[13]
GO_term GO:0016624 IEA Inferred_automatically
GO:0008152 IEA Inferred_automatically
Structured_description Provisional_description Y39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial.Paper_evidenceWBPaper00004424
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
This gene encodes a protein predicted by Eisenberg and coworkers, with 68% accuracy, to be mitochondrial.
Proteins localized to a given organelle by experiments tend to share a characteristic phylogenetic distribution of their homologs, called a phylogenetic profile.
For instance, mitochondrial proteins can be identified effectively by their phylogenetic profiles.
By applying phylogenetic profile analysis to the C. elegans genome, Eisenberg and coworkers inferred that this gene, along with 2-4% of all the nuclear genes in C. elegans, encodes a mitochondrial protein.
The large fraction of organism-specific and eukaryote-derived genes suggests that C. elegans mitochondria perform specialized roles absent from prokaryotic mitochondrial ancestors.
Concise_descriptionY39E4A.3 is orthologous to the human gene MAPLE SYRUP URINE DISEASE, TYPE IA (MSUD, TYPE IA; E1-alpha subunit of branched-chain keto acid dehydrogenase; OMIM:248600), which when mutated leads to maple syrup urine disease; Y39E4A.3 protein is predicted to be mitochondrial.
Molecular_info (5)
Experimental_info RNAi_result Cenix:321-a9
JA:Y39E4A.3
WB_RNAi_result (5)
Y2H_bait Y2H001944
Y2H008556
Y2H008557
MethodGene