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Gene: Y39G10AR.13   

Y39G10AR.13SMapS_parentSequenceY39G10AR
ChromosomeI
Identity (5)
Gene_info Gene_classicp
Contained_in_operonCEOP1910
Structured_description Provisional_description The icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development.Paper_evidenceWBPaper00004735
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
The mitotic chromosome segregation defects seen in icp-1(RNAi) embryos are distinct from those induced by depletion of centromeric proteins such as HCP-3 or HCP-4; defects are seen before and during anaphase, but chromatin splits into two equally sized masses instead of failing to segregate, and mechanically stable spindles do arise (unlike in hcp-3(RNAi) or hcp-4(RNAi) embryos), which are defective later in anaphase and telophase.
Kinetochore assembly is apparently normal in icp-1(RNAi) embryos.
Concise_descriptionThe icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development.
Molecular_info (6)
Experimental_info RNAi_result TH:144-f1
JA:Y39G10A_246.i
Simmer:Y39G10A_246.i:Screen_A
Simmer:Y39G10A_246.i:Screen_B
WB_RNAi_result (5)
Expr_patternExpr1891
Y2H_targetY2H007021
Reference (9)
RemarkSequence connection from [Oegema K, Hyman AA]. krb 13/11/01
MethodGene