Gene: Y39G10AR.13
Y39G10AR.13 | SMap | S_parent | Sequence | Y39G10AR | |||||
---|---|---|---|---|---|---|---|---|---|
Chromosome | I | ||||||||
Identity | Version | 1 | |||||||
Name (7) | |||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Gene_class | icp | |||||||
Contained_in_operon | CEOP1910 | ||||||||
Structured_description | Provisional_description | The icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development. | Paper_evidence | WBPaper00004735 | |||||
Person_evidence | WBPerson567 | ||||||||
Curator_confirmed | WBPerson567 | ||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
The mitotic chromosome segregation defects seen in icp-1(RNAi) embryos are distinct from those induced by depletion of centromeric proteins such as HCP-3 or HCP-4; defects are seen before and during anaphase, but chromatin splits into two equally sized masses instead of failing to segregate, and mechanically stable spindles do arise (unlike in hcp-3(RNAi) or hcp-4(RNAi) embryos), which are defective later in anaphase and telophase. | |||||||||
Kinetochore assembly is apparently normal in icp-1(RNAi) embryos. | |||||||||
Concise_description | The icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development. | ||||||||
Molecular_info (6) | |||||||||
Experimental_info | RNAi_result | TH:144-f1 | |||||||
JA:Y39G10A_246.i | |||||||||
Simmer:Y39G10A_246.i:Screen_A | |||||||||
Simmer:Y39G10A_246.i:Screen_B | |||||||||
WB_RNAi_result (5) | |||||||||
Expr_pattern | Expr1891 | ||||||||
Y2H_target | Y2H007021 | ||||||||
Reference (9) | |||||||||
Remark | Sequence connection from [Oegema K, Hyman AA]. krb 13/11/01 | ||||||||
Method | Gene |