Y39G10AR.13 | SMap | S_parent | Sequence | Y39G10AR
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| Chromosome | I |
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Identity (5)
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Gene_info
| Gene_class | icp
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| | Contained_in_operon | CEOP1910
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Structured_description
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Provisional_description
| The icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development. | Paper_evidence | WBPaper00004735
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
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| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | The mitotic chromosome segregation defects seen in icp-1(RNAi) embryos are distinct from those induced by depletion of centromeric proteins such as HCP-3 or HCP-4; defects are seen before and during anaphase, but chromatin splits into two equally sized masses instead of failing to segregate, and mechanically stable spindles do arise (unlike in hcp-3(RNAi) or hcp-4(RNAi) embryos), which are defective later in anaphase and telophase. |
| | | | Kinetochore assembly is apparently normal in icp-1(RNAi) embryos. |
| | | Concise_description | The icp-1 gene encodes a 'chromosomal passenger protein'; inactivation of icp-1 by RNAi leads to a complete failure of chromosome segregation during the first mitotic division of embryonic development. |
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Molecular_info (6)
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Experimental_info
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RNAi_result (4)
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WB_RNAi_result (5)
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| | Expr_pattern | Expr1891
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| | Y2H_target | Y2H007021
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Reference (9)
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| Remark | Sequence connection from [Oegema K, Hyman AA]. krb 13/11/01 |
| Method | Gene
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