RNAiDB Tree View

Gene: Y48G8AR.1

Y48G8AR.1	Evidence	Author_evidence	Venkatesan K
	SMap	S_parent	Sequence	Y48G8AR
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	grh
		Allele (5)
		Structured_description	Provisional_description	grh-1 encodes a LSF/GRH transcription factor homolog required for normal cuticular synthesis and embryonic development; both GRH-1 and its Drosophila homolog GRAINYHEAD bind to DNA sites upstream of dbl-1, mab-5, and tdc-1; all three of these target genes are homologs of genes regulated by GRAINYHEAD in Drosophila; grh-1(RNAi) animals die as embryos with soft, defective cuticles, which resembles the phenotype seen in Drosophila grainyhead mutants.	Paper_evidence	WBPaper00006017
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				The family of transcription factors to which GRH-1 belongs has two subdivisions, the Grainyhead and LSF subfamilies, whose split phylogenetically preceded the divergence of metazoa.
			Concise_description	grh-1 encodes a LSF/GRH transcription factor homolog required for normal cuticular synthesis and embryonic development; both GRH-1 and its Drosophila homolog GRAINYHEAD bind to DNA sites upstream of dbl-1, mab-5, and tdc-1; all three of these target genes are homologs of genes regulated by GRAINYHEAD in Drosophila; grh-1(RNAi) animals die as embryos with soft, defective cuticles, which resembles the phenotype seen in Drosophila grainyhead mutants.
	Molecular_info (8)
	Experimental_info	RNAi_result	JA:Y48G8A_3671.a
			Simmer:Y48G8A_3671.a:Screen_A
			Simmer:Y48G8A_3671.a:Screen_B
			Cenix:99-c6
		WB_RNAi_result	JA:Y48G8A_3671.a
			Simmer:Y48G8A_3671.a:Screen_A
			Simmer:Y48G8A_3671.a:Screen_B
			Cenix:99-c6
		Expr_pattern	Expr2620
	Reference	WBPaper00006017
	Method	Gene