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Gene: Y54F10AL.2   

Y54F10AL.2EvidencePerson_evidenceWBPerson7
SMapS_parentSequenceY54F10AL
ChromosomeIII
Identity (5)
Gene_info Gene_classest
Alleletm1308
Structured_description Provisional_description est-1 encodes two isoforms of a putative telomerase subunit orthologous to human EST1A (KIAA0732), Drosophila CG6369, and (more distantly) to S. cerevisiae EST1; EST-1A/B proteins have, from their N- to C-termini, an EST domain, one and a half tetratricopeptide repeats (TPRs), and a PilT amino-terminal (PIN) domain; the first two domains are shared with both metazoan and fungal EST1 orthologs, while the PIN domain is found only in metazoan EST1s; although it seems likely to be required for long-term maintenance of the germline (perhaps by recruiting telomerase to telomeres), est-1 has no obvious function in mass RNAi assays. Paper_evidence WBPaper00004651
WBPaper00013250
WBPaper00013251
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
The domain organization of EST-1 is partly shared by SMG-5, which has the TPR and PIN domains.
Concise_descriptionest-1 encodes two isoforms of a putative telomerase subunit orthologous to human EST1A (KIAA0732), Drosophila CG6369, and (more distantly) to S. cerevisiae EST1; EST-1A/B proteins have, from their N- to C-termini, an EST domain, one and a half tetratricopeptide repeats (TPRs), and a PilT amino-terminal (PIN) domain; the first two domains are shared with both metazoan and fungal EST1 orthologs, while the PIN domain is found only in metazoan EST1s; although it seems likely to be required for long-term maintenance of the germline (perhaps by recruiting telomerase to telomeres), est-1 has no obvious function in mass RNAi assays.
Molecular_info (5)
Experimental_info RNAi_result Cenix:178-a3
Cenix:56-g10
WB_RNAi_result SA:yk254h10
MV_SV:mv_Y54F10AL.a
Cenix:178-a3
Cenix:56-g10
Y2H_targetY2H011045
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene