Y54F10AL.2 | Evidence | Person_evidence | WBPerson7
|
| SMap | S_parent | Sequence | Y54F10AL
|
| Chromosome | III |
|
Identity (5)
|
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Gene_info
| Gene_class | est
|
| | Allele | tm1308
|
| |
Structured_description
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Provisional_description
| est-1 encodes two isoforms of a putative telomerase subunit orthologous to human EST1A (KIAA0732), Drosophila CG6369, and (more distantly) to S. cerevisiae EST1; EST-1A/B proteins have, from their N- to C-termini, an EST domain, one and a half tetratricopeptide repeats (TPRs), and a PilT amino-terminal (PIN) domain; the first two domains are shared with both metazoan and fungal EST1 orthologs, while the PIN domain is found only in metazoan EST1s; although it seems likely to be required for long-term maintenance of the germline (perhaps by recruiting telomerase to telomeres), est-1 has no obvious function in mass RNAi assays. |
Paper_evidence
| WBPaper00004651
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| | | | | | WBPaper00013250
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| | | | | | WBPaper00013251
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| | | | | Person_evidence | WBPerson567
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| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | The domain organization of EST-1 is partly shared by SMG-5, which has the TPR and PIN domains. |
| | | Concise_description | est-1 encodes two isoforms of a putative telomerase subunit orthologous to human EST1A (KIAA0732), Drosophila CG6369, and (more distantly) to S. cerevisiae EST1; EST-1A/B proteins have, from their N- to C-termini, an EST domain, one and a half tetratricopeptide repeats (TPRs), and a PilT amino-terminal (PIN) domain; the first two domains are shared with both metazoan and fungal EST1 orthologs, while the PIN domain is found only in metazoan EST1s; although it seems likely to be required for long-term maintenance of the germline (perhaps by recruiting telomerase to telomeres), est-1 has no obvious function in mass RNAi assays. |
|
Molecular_info (5)
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Experimental_info
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RNAi_result
| Cenix:178-a3
|
| | | Cenix:56-g10
|
| |
WB_RNAi_result
| SA:yk254h10
|
| | | MV_SV:mv_Y54F10AL.a
|
| | | Cenix:178-a3
|
| | | Cenix:56-g10
|
| | Y2H_target | Y2H011045
|
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene
|