Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: Y56A3A.13   

Y56A3A.13SMapS_parentSequenceY56A3A
ChromosomeIII
Identity (5)
Gene_info Gene_classnft
Contained_in_operonCEOP3744
Structured_description Provisional_description The nft-1 gene encodes an ortholog of human FHIT, which when mutated is associated with head and neck cancers (OMIM:601153). Paper_evidence WBPaper00004103
WBPaper00012802
WBPaper00013573
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Heterozygous mutation of the mouse FHIT gene, combined with a tumor-promoting chemical, leads to a mixture of adenomas, squamous paillomas, invasive carcinomas of the forestomach, and tumors of sebaceous glands.
The FHIT protein itself is an diadenosine-5',5'''-P(1),P(3)-triphosphate (AP3A) hydrolase (EC 3.6.1.29) that has been proposed to regulate DNA replication or signal stress responses.
Concise_descriptionThe nft-1 gene encodes an ortholog of human FHIT, which when mutated is associated with head and neck cancers (OMIM:601153).
Molecular_info (6)
Experimental_info RNAi_result Cenix:332-f1
TH:332F1
WB_RNAi_result TH:332F1
MV_SV:mv_Y56A3A.13
Cenix:332-f1
Expr_patternExpr5961
Y2H_target Y2H001807
Y2H001810
Reference WBPaper00003154
WBPaper00004320
RemarkY56A3A.V changed to .13 following from sequence annotation. [sdm 05/00]
MethodGene