RNAiDB Tree View

Gene: Y66A7A.6

Y66A7A.6	SMap	S_parent	Sequence	Y66A7AR
	Chromosome	III
	Identity (5)
	Gene_info	Gene_class	gly
		Allele	tm1156
		Structured_description	Provisional_description	gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known.	Paper_evidence	WBPaper00003042
						WBPaper00005408
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
				GLY-8 is distinct from other C. elegans GalNAc transferases in that it does not contain a C-terminal ricin-like lectin domain, the function of which is not yet known.
			Concise_description	gly-8 encodes a predicted transmembrane polypeptide N-acetylgalactosaminyl transferase (ppGaNTase) similar to the essential Drosophila ppGaNTase encoded by Pgant35A; by homology, GLY-8 is predicted to function as a Golgi enzyme that catalyzes transfer of N-acetylgalactosamine to serine and threonine-containing acceptor peptides, thus initiating mucin-type O-glycosylation; as loss of gly-8 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GLY-8 in C. elegans development and/or behavior is not yet known.
	Molecular_info (6)
	Experimental_info	RNAi_result (5)
		WB_RNAi_result (6)
		Y2H_target	Y2H006313
			Y2H008352
	Reference	WBPaper00003042
		WBPaper00017620
		WBPaper00005408
		WBPaper00026630
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene