RNAiDB Tree View

Gene: ZC477.9

ZC477.9	SMap	S_parent	Sequence	ZC477
	Chromosome	IV
	Identity (5)
	Gene_info	Gene_class	deb
		Reference_allele	st555
		Allele	st385
			st554	Inferred_automatically	From strain object: RW3616
			st555	Inferred_automatically	From strain object: RW3562
		Phenotype	[Williams BD] Pat (embryonic arrest), severe paralysis
			[C.elegansII] st385amb : Pat (paralysed embryonic arrest at 2-fold); disorganized muscle; some pharyngeal pumping. OA1: st555 (similar).Cloned: encodes dense body component, vinculin. [Barstead and Waterston 1991; Williams and Waterston 1994]
			[Williams BD] Severe Pat phenotype; some pharyngeal pumping.
			[C.elegansII] st554 : severe Pat phenotype; some pharyngeal pumping. [Williams and Waterston 1994; RW]
		Strain	RW3562
			RW3616
		GO_term	GO:0005198	IEA	Inferred_automatically
			GO:0045296	IEA	Inferred_automatically
			GO:0007155	IEA	Inferred_automatically
			GO:0015629	IEA	Inferred_automatically
		Structured_description	Provisional_description	The deb-1 gene encodes a vinculin ortholog highly conserved amongst metazoans including Drosophila, chick, and humans (OMIM:193065); DEB-1 is a muscle attachment protein found in dense bodies, and is required for attaching actin thin filaments to the basal sarcolemma; DEB-1 requires PAT-4/integrin-linked kinase for full assembly into nascent attachments.	Paper_evidence	WBPaper00001160
						WBPaper00005261
					Curator_confirmed	WBPerson1843
					Date_last_updated	14 Feb 2005 00:00:00
				The deb-1 gene encodes a vinculin ortholog highly conserved amongst metazoans including Drosophila, chick, and humans (OMIM:193065); DEB-1 is a muscle attachment protein found in dense bodies and M lines and is required for attaching actin and myosin filaments to the basal sarcolemma; DEB-1 requires PAT-4/integrin-linked kinase for full assembly into nascent attachments.	Paper_evidence	WBPaper00001160
						WBPaper00005261
					Person_evidence	WBPerson1843
			Concise_description	The deb-1 gene encodes a vinculin ortholog highly conserved amongst metazoans including Drosophila, chick, and humans (OMIM:193065); DEB-1 is a muscle attachment protein found in dense bodies, and is required for attaching actin thin filaments to the basal sarcolemma; DEB-1 requires PAT-4/integrin-linked kinase for full assembly into nascent attachments.
				The deb-1 gene encodes a vinculin ortholog highly conserved amongst metazoans including Drosophila, chick, and humans (OMIM:193065); DEB-1 is a muscle attachment protein found in dense bodies and M lines and is required for attaching actin and myosin filaments to the basal sarcolemma; DEB-1 requires PAT-4/integrin-linked kinase for full assembly into nascent attachments.
	Molecular_info	Corresponding_CDS	ZC477.9a
			ZC477.9b
			ZC477.9c
		Corresponding_protein	WP:CE31396
			WP:CE31397
			WP:CE31398
		Corresponding_RNAi_reagent	Cenix:54-c6
			mv_AAA28002
	Experimental_info	RNAi_result	Cenix:54-c6
		WB_RNAi_result	MV_SV:mv_AAA28002
			Cenix:54-c6
		Y2H_target	Y2H001580
	Reference (38)
	Remark	Data extracted from Williams & Waterston 1994
		pat-8 gene has been merged with deb-1 and is now an other name of deb-1. This was done following instruction from the CGC. [krb 030512]
	Method	Gene