| | | [C.elegansII] mn23 : early larval lethal. OA>15: sy15(rod-like early larval lethal, probable null), sy5 (similar tosy15, W1078op), mn224 (earlylarval lethal, non-null), n1045 (homozygousviable, Vul at 15C, weak Muv (hyperinduced) at25C; P12 transformed to P11 fate), sy1 (viable, Vul, Q1318och), sy97 (viable,Vul, ME0, abnormal spicules), sy10 (impenetrant larval lethal, survivors sterile, Emo, abnormal oocytes), etc.Alleles affect subset or all of 5 phenotypes (L1 viability, vulval induction, male spicules,oogenesis, P12). Also gf allele sa62sd (scrawny Muv, sa62/+ variable Muv, 5-50%) Cloned: 4.9 kb transcript, encodes 1323 aa EGF-receptor class tyrosine kinase (pka kin-7);let23:lacZ expressed in many but not all cells.Extensive molecular and developmental analysis.See also lfe, sli, etc. [Sigurdson et al. 1984; Aroian et al. 1990; Aroian and Sternberg 1991; Aroian et al. 1994; Koga and Ohshima 1995; FK; SP] |
| |
Structured_description
| Provisional_description | The let-23 gene encodes a member of the EGF-receptor family of transmembrane tyrosine kinases that affects viability, inductive signaling during development of the vulva, male spicule formation, posterior development of the epidermis, and ovulation; it is genetically upstream of the let-60/RAS pathway with respect to viability and vulval development, is upstream of the IP3 pathway with respect to fertility, and is expressed in vulval precursor cells. | Person_evidence | WBPerson567
|
| | | Concise_description | The let-23 gene encodes a member of the EGF-receptor family of transmembrane tyrosine kinases that affects viability, inductive signaling during development of the vulva, male spicule formation, posterior development of the epidermis, and ovulation; it is genetically upstream of the let-60/RAS pathway with respect to viability and vulval development, is upstream of the IP3 pathway with respect to fertility, and is expressed in vulval precursor cells. |