ZK354.4 | SMap | S_parent | Sequence | ZK354
|
| Chromosome | IV |
|
Identity (5)
|
|
Gene_info
| Gene_class | msp
|
| |
Phenotype
| Cluster of six genes including msp-19 and msp-113 (both transcribed). |
| | | [C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of at least six genes including msp-19 and msp-113 (both transcribed). [Ward et al. (1988); BA] |
| | GO_term | GO:0005198
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | msp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
Paper_evidence
| WBPaper00001023
|
| | | | | | WBPaper00002143
|
| | | | | | WBPaper00003744
|
| | | | | | WBPaper00004280
|
| | | | | | WBPaper00004591
|
| | | | | | WBPaper00005670
|
| | | | | Curator_confirmed | WBPerson324
|
| | | | | Date_last_updated | 04 May 2005 00:00:00 |
| | | Concise_description | msp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
|
Molecular_info
| Corresponding_CDS | ZK354.4
|
| | Corresponding_protein | WP:CE02806
|
| |
Corresponding_PCR_product
| smd_C04G2.4
|
| | | smd_C34F11.4
|
| | | smd_C34F11.6
|
| | | smd_F32B6.6
|
| | | smd_F36H12.7
|
| | | smd_F36H12.7:2
|
| | | smd_F36H12.8
|
| | | smd_F58A6.9
|
| | | smd_K07F5.2
|
| | | smd_K07F5.3
|
| | | smd_K08F4.8
|
| | | smd_R05F9.3
|
| | | smd_R13H9.2
|
| | | smd_R13H9.2:2
|
| | | smd_R13H9.4
|
| | | smd_T13F2.10
|
| | | smd_T13F2.11
|
| | | smd_Y4C6A.c
|
| | | smd_Y59E9_120.c
|
| | | smd_ZK354.1
|
| | | smd_ZK354.4
|
| | | smd_ZK354.11
|
| | | smd_ZK546.6
|
| | | smd_ZK1251.6
|
| | | sjj_K08F4.8
|
| | | sjj_ZK546.6
|
| | | sjj_R13H9.4
|
| | | sjj_C34F11.6
|
| | | sjj_Y59E9_120.c
|
| | | sjj_ZK354.5
|
| | | sjj_ZK354.1
|
| | | sjj_R05F9.13
|
| | | sjj_F26G1.7
|
| | | sjj_R05F9.8
|
| | | sjj_T13F2.11
|
| | | sjj_T13F2.10
|
| | | sjj_K07F5.1
|
| | | sjj_ZK1248.6
|
| | | sjj_K07F5.2
|
| | | sjj_R13H9.2
|
| | | sjj_ZK1251.6
|
| | | sjj_Y4C6A.c
|
| | | sjj_C04G2.4
|
| | | sjj_R05F9.5
|
| | | sjj_ZK354.11
|
| | | sjj_F58A6.11
|
| | | sjj_C09B9.6
|
| | | sjj_F09C12.7
|
| | | sjj_C34F11.4
|
| | | sjj_F32B6.6
|
| | | sjj_Y59E9_120.c_1
|
| | | sjj_R05F9.3
|
| | | sjj_F58A6.8
|
| | | sjj_ZK354.4
|
| | | sjj_F36H12.7
|
| | | sjj_Y59E9_120.c_2
|
| | | sjj_K07F5.3
|
| |
Corresponding_RNAi_reagent (67)
|
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Experimental_info
|
RNAi_result
| Cenix:13-d7
|
| | | JA:ZK354.4
|
| |
WB_RNAi_result (65)
|
| | Expr_pattern | Expr3417
|
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Reference (6)
|
| Method | Gene
|