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Gene: ZK354.4   

ZK354.4SMapS_parentSequenceZK354
ChromosomeIV
Identity (5)
Gene_info Gene_classmsp
Phenotype Cluster of six genes including msp-19 and msp-113 (both transcribed).
[C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of at least six genes including msp-19 and msp-113 (both transcribed). [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence (6)
Curator_confirmedWBPerson324
Date_last_updated04 May 2005 00:00:00
Concise_descriptionmsp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSZK354.4
Corresponding_proteinWP:CE02806
Corresponding_PCR_product (57)
Corresponding_RNAi_reagent Cenix:13-d7
sjj_ZK354.4
sjj_C04G2.4
mv_ZK354.4
sjj_ZK354.11
sjj_R05F9.8
Cenix:14-e7
sjj_C34F11.4
sjj_F32B6.6
Cenix:203-f6
Cenix:13-d1
sjj_R13H9.2
sjj_ZK354.1
mv_ZK1251.6
sjj_C34F11.6
yk381d1
mv_C34F11.4
sjj_K08F4.8
sjj_F36H12.7
sjj_F58A6.8
sjj_R05F9.3
mv_ZK1248.6
Cenix:16-c9
sjj_ZK546.6
Cenix:242-d2
mv_F36H12.7
mv_C34F11.6
sjj_K07F5.3
sjj_F26G1.7
Cenix:246-b8
yk380e3
Cenix:13-c7
Cenix:242-c6
sjj_Y59E9_120.c
Cenix:242-h7
Cenix:243-c6
Cenix:242-h2
sjj_K07F5.1
mv_C09B9.6
mv_F26G1.7
Cenix:211-g4
sjj_R05F9.13
sjj_T13F2.11
Cenix:247-a1
Cenix:205-e12
Cenix:14-g4
Cenix:245-g4
mv_ZK546.6
sjj_Y4C6A.c
sjj_T13F2.10
Cenix:13-f11
sjj_K07F5.2
sjj_F09C12.7
yk384g8
sjj_R13H9.4
mv_R05F9.8
sjj_ZK1251.6
sjj_ZK1248.6
mv_Y59H11AM.d
sjj_C09B9.6
yk386a12
yk387c2
yk370d1
sjj_ZK354.5
mv_F32B6.6
Cenix:242-g2
Cenix:242-g7
Experimental_info RNAi_result Cenix:13-d7
JA:ZK354.4
WB_RNAi_result (65)
Expr_patternExpr3417
Reference (6)
MethodGene