Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: ZK354.4   

ZK354.4SMapS_parentSequenceZK354
ChromosomeIV
Identity (5)
Gene_info Gene_classmsp
Phenotype Cluster of six genes including msp-19 and msp-113 (both transcribed).
[C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of at least six genes including msp-19 and msp-113 (both transcribed). [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence WBPaper00001023
WBPaper00002143
WBPaper00003744
WBPaper00004280
WBPaper00004591
WBPaper00005670
Curator_confirmedWBPerson324
Date_last_updated04 May 2005 00:00:00
Concise_descriptionmsp-113 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-113 has a C. briggsae homolog as detected by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; the msp-113 promoter region contains two conserved cis elements that are recognition sites for elt-1, a gene that encodes a homolog of the vertebrate GATA transcription factor family; this suggests that a MSP protein is a potential target for ELT-1 in the germ-line; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSZK354.4
Corresponding_proteinWP:CE02806
Corresponding_PCR_product (57)
Corresponding_RNAi_reagent (67)
Experimental_info RNAi_result Cenix:13-d7
JA:ZK354.4
WB_RNAi_result (65)
Expr_patternExpr3417
Reference (6)
MethodGene