RNAiDB Tree View

Gene: ZK546.6

ZK546.6	SMap	S_parent	Sequence	ZK546
	Chromosome	II
	Identity (5)
	Gene_info	Gene_class	msp
		Phenotype	Cluster of five genes including msp-152 (transcribed).
			[C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of five genes including msp-152 (transcribed). [Ward et al. (1988); BA]
		GO_term	GO:0005198	IEA	Inferred_automatically
		Structured_description	Provisional_description	msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.	Paper_evidence	WBPaper00001023
						WBPaper00002143
						WBPaper00003113
						WBPaper00004591
						WBPaper00005670
					Curator_confirmed	WBPerson324
					Date_last_updated	17 May 2005 00:00:00
			Concise_description	msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
	Molecular_info	Corresponding_CDS	ZK546.6
		Corresponding_protein	WP:CE02920
		Corresponding_PCR_product	smd_C34F11.4
			smd_F32B6.6
			smd_F36H12.7
			smd_F36H12.7:2
			smd_F36H12.8
			smd_F58A6.9
			smd_K07F5.2
			smd_R05F9.3
			smd_R13H9.4
			smd_T13F2.10
			smd_Y59E9_120.c
			smd_ZK354.1
			smd_ZK354.11
			smd_ZK546.3
			smd_ZK546.6
			smd_ZK1251.6
			sjj_ZK546.6
			sjj_R13H9.4
			sjj_Y59E9_120.c
			sjj_ZK354.1
			sjj_R05F9.13
			sjj_F26G1.7
			sjj_R05F9.8
			sjj_T13F2.10
			sjj_K07F5.2
			sjj_ZK1251.6
			sjj_R05F9.5
			sjj_ZK354.11
			sjj_F09C12.7
			sjj_C34F11.4
			sjj_F32B6.6
			sjj_Y59E9_120.c_1
			sjj_R05F9.3
			sjj_ZK546.3
			sjj_F58A6.8
			sjj_F36H12.7
			sjj_Y59E9_120.c_2
		Corresponding_RNAi_reagent (40)
	Experimental_info	RNAi_result	JA:ZK546.6
			Simmer:ZK546.6:Repeat_a
			Simmer:ZK546.6:Repeat_b
			Simmer:ZK546.6:Screen
		WB_RNAi_result (69)
		Expr_pattern	Expr3417
	Reference	WBPaper00001023
		WBPaper00001024
		WBPaper00024312
		WBPaper00025088
	Method	Gene