ZK546.6 | SMap | S_parent | Sequence | ZK546
|
| Chromosome | II |
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Identity (5)
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Gene_info
| Gene_class | msp
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Phenotype
| Cluster of five genes including msp-152 (transcribed). |
| | | [C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of five genes including msp-152 (transcribed). [Ward et al. (1988); BA] |
| | GO_term | GO:0005198
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
Paper_evidence (5)
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| | | | | Curator_confirmed | WBPerson324
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| | | | | Date_last_updated | 17 May 2005 00:00:00 |
| | | Concise_description | msp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
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Molecular_info (4)
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Experimental_info (3)
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Reference
| WBPaper00001023
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| | WBPaper00001024
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| | WBPaper00024312
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| | WBPaper00025088
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| Method | Gene
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