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Gene: ZK546.6   

ZK546.6SMapS_parentSequenceZK546
ChromosomeII
Identity (5)
Gene_info Gene_classmsp
Phenotype Cluster of five genes including msp-152 (transcribed).
[C.elegansII] NMK. Encodes MSP (16kD). Defines cluster of five genes including msp-152 (transcribed). [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence (5)
Curator_confirmedWBPerson324
Date_last_updated17 May 2005 00:00:00
Concise_descriptionmsp-152 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSZK546.6
Corresponding_proteinWP:CE02920
Corresponding_PCR_product (37)
Corresponding_RNAi_reagent (40)
Experimental_info RNAi_result JA:ZK546.6
Simmer:ZK546.6:Repeat_a
Simmer:ZK546.6:Repeat_b
Simmer:ZK546.6:Screen
WB_RNAi_result (69)
Expr_patternExpr3417
Reference (4)
MethodGene