Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 

Gene: ZK637.8   

ZK637.8SMapS_parentSequenceZK637
ChromosomeIII
Identity (5)
Gene_info Gene_classunc
Reference_allelee189
Allele (5)
Phenotype e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation).
[Thierry-Mieg]
See also eIs16, f120, f121, f123
[C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC]
Strain (273)
GO_term GO:0015992 IEA Inferred_automatically
GO:0016020 IEA Inferred_automatically
Contained_in_operonCEOP3556
Structured_description Provisional_description unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.Paper_evidenceWBPaper00004601
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
unc-32 is one of four C. elegans genes encoding V-ATPase a subunits along with vha-5, vha-6, and vha-7.
Each of these genes generally demonstrates tissue-specific, nonoverlapping expression.
Concise_descriptionunc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.
Molecular_info (6)
Experimental_info RNAi_result (6)
WB_RNAi_result (8)
Expr_pattern Expr21
Expr848
Expr849
Expr2405
Reference (109)
MethodGene