RNAiDB Tree View

Gene: ZK637.8

ZK637.8	SMap	S_parent	Sequence	ZK637
	Chromosome	III
	Identity	Version	1
		Name (6)
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:42	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Gene_class	unc
		Reference_allele	e189
		Allele (5)
		Phenotype	e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation).
			[Thierry-Mieg]
			See also eIs16, f120, f121, f123
			[C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC]
		Strain (273)
		GO_term	GO:0015992	IEA	Inferred_automatically
			GO:0016020	IEA	Inferred_automatically
		Contained_in_operon	CEOP3556
		Structured_description	Provisional_description	unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.	Paper_evidence	WBPaper00004601
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
				unc-32 is one of four C. elegans genes encoding V-ATPase a subunits along with vha-5, vha-6, and vha-7.
				Each of these genes generally demonstrates tissue-specific, nonoverlapping expression.
			Concise_description	unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.
	Molecular_info (6)
	Experimental_info	RNAi_result (6)
		WB_RNAi_result (8)
		Expr_pattern	Expr21
			Expr848
			Expr849
			Expr2405
	Reference (109)
	Method	Gene