ZK637.8 | SMap | S_parent | Sequence | ZK637
|
| Chromosome | III |
|
Identity (5)
|
|
Gene_info
| Gene_class | unc
|
| | Reference_allele | e189
|
| |
Allele (5)
|
| |
Phenotype
| e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation). |
| | | [Thierry-Mieg] |
| | | See also eIs16, f120, f121, f123 |
| | | [C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC] |
| |
Strain
| BA676
|
| | | BB1
|
| | | BC4142
|
| | | BC4143
|
| | | BC4144
|
| | | BC4145
|
| | | BC4148
|
| | | BC4149
|
| | | BC4151
|
| | | BC4152
|
| | | BC4153
|
| | | BC4154
|
| | | BC4155
|
| | | BC4156
|
| | | BC4157
|
| | | BC4159
|
| | | BC4163
|
| | | BC4164
|
| | | BC4165
|
| | | BC4166
|
| | | BC4167
|
| | | BC4168
|
| | | BC4171
|
| | | BC4172
|
| | | BC4173
|
| | | BC4179
|
| | | BC4181
|
| | | BC4185
|
| | | BC4186
|
| | | BC4187
|
| | | BC4188
|
| | | BC4190
|
| | | BC4192
|
| | | BC4212
|
| | | BC4213
|
| | | BC4216
|
| | | BC4218
|
| | | BC4219
|
| | | BC4222
|
| | | BC4224
|
| | | BC4225
|
| | | BC4227
|
| | | BC4229
|
| | | BC4231
|
| | | BC4233
|
| | | BC4235
|
| | | BC4237
|
| | | BC4241
|
| | | BC4242
|
| | | BC4243
|
| | | BC4245
|
| | | BC4246
|
| | | BC4247
|
| | | BC4249
|
| | | BC4253
|
| | | BC4255
|
| | | BC4256
|
| | | BC4258
|
| | | BC4259
|
| | | BC4261
|
| | | BC4262
|
| | | BC4267
|
| | | BC4270
|
| | | BC4271
|
| | | BC4634
|
| | | BC4637
|
| | | BC4638
|
| | | BC4677
|
| | | BC4696
|
| | | BC4697
|
| | | BC4799
|
| | | BC4822
|
| | | BC4823
|
| | | BC4824
|
| | | BC4825
|
| | | BC4826
|
| | | BC4827
|
| | | BC4828
|
| | | BC4829
|
| | | BC4831
|
| | | BC4832
|
| | | BC4833
|
| | | BC4834
|
| | | BC4835
|
| | | BC4836
|
| | | BC4838
|
| | | BC4841
|
| | | BC4843
|
| | | BC4844
|
| | | BC4845
|
| | | BC4846
|
| | | BC4847
|
| | | BC4848
|
| | | BC4849
|
| | | BC4850
|
| | | BC4851
|
| | | BC4852
|
| | | BC4853
|
| | | BC4854
|
| | | BC4855
|
| | | BC4856
|
| | | BC4857
|
| | | BC4858
|
| | | BC4859
|
| | | BC4860
|
| | | BC4862
|
| | | BC4863
|
| | | BC4864
|
| | | BC4865
|
| | | BC4866
|
| | | BC4867
|
| | | BC4868
|
| | | BC4869
|
| | | BC4870
|
| | | BC4873
|
| | | BC4874
|
| | | BC4875
|
| | | BC4876
|
| | | BC4878
|
| | | BC4879
|
| | | BC4880
|
| | | BC4881
|
| | | BC4882
|
| | | BC4883
|
| | | BC4997
|
| | | BC5078
|
| | | BS913
|
| | | BW1369
|
| | | CB189
|
| | | CB1918
|
| | | CB2195
|
| | | CB2196
|
| | | CB2206
|
| | | CB4118
|
| | | CH1180
|
| | | CX2914
|
| | | DA589
|
| | | DG769
|
| | | DG783
|
| | | DG784
|
| | | DG786
|
| | | DG800
|
| | | DG801
|
| | | DG815
|
| | | DR129
|
| | | DR130
|
| | | DR133
|
| | | DR284
|
| | | DR410
|
| | | EH250
|
| | | EL69
|
| | | FF275
|
| | | FF276
|
| | | FF451
|
| | | FF628
|
| | | GE2244
|
| | | GE1825
|
| | | GE2167
|
| | | GE2171
|
| | | GE2172
|
| | | GE2175
|
| | | GE2180
|
| | | GE2198
|
| | | GE2199
|
| | | GE2204
|
| | | GE2211
|
| | | GE2219
|
| | | GE2238
|
| | | GE2239
|
| | | GE2240
|
| | | GE2242
|
| | | GE2245
|
| | | GE2255
|
| | | GE2259
|
| | | GE2345
|
| | | GE2349
|
| | | GE2353
|
| | | GE2358
|
| | | GE2364
|
| | | GE2533
|
| | | GE2534
|
| | | GE2576
|
| | | GE2606
|
| | | GE2614
|
| | | GE2626
|
| | | GE2628
|
| | | GE2629
|
| | | GE2633
|
| | | GE2636
|
| | | GE2638
|
| | | GE2656
|
| | | GE2659
|
| | | GE2663
|
| | | GE2685
|
| | | GE2690
|
| | | GE2720
|
| | | GE2722
|
| | | GE2723
|
| | | GE2727
|
| | | GE2730
|
| | | GE2929
|
| | | GE2935
|
| | | GE2940
|
| | | GE2941
|
| | | GE2946
|
| | | GE2948
|
| | | GE2952
|
| | | GE2959
|
| | | GE2961
|
| | | GE3023
|
| | | GE3841
|
| | | GS60
|
| | | GS107
|
| | | GS311
|
| | | GS316
|
| | | GS320
|
| | | GS328
|
| | | GS387
|
| | | GS776
|
| | | GS807
|
| | | GS878
|
| | | GS883
|
| | | HY463
|
| | | JK633
|
| | | JK892
|
| | | JK948
|
| | | JK966
|
| | | JK967
|
| | | JK968
|
| | | JK1122
|
| | | JK1129
|
| | | JK1505
|
| | | LB128
|
| | | MH37
|
| | | MT465
|
| | | MT688
|
| | | MT706
|
| | | MT1373
|
| | | MT1422
|
| | | MT1799
|
| | | MT1908
|
| | | MT1909
|
| | | MT2343
|
| | | MT2351
|
| | | MT3022
|
| | | MT3025
|
| | | MT3751
|
| | | MT4009
|
| | | MT4500
|
| | | MT4947
|
| | | MT4979
|
| | | MT4997
|
| | | MT5000
|
| | | NG2618
|
| | | OH2638
|
| | | OH2639
|
| | | PJ1153
|
| | | PJ1158
|
| | | PS2943
|
| | | RW1522
|
| | | SP17
|
| | | SP462
|
| | | SP471
|
| | | ST20
|
| | | ST21
|
| | | ST22
|
| | | ST35
|
| | | TY415
|
| | | TY562
|
| | | TY567
|
| | | TY578
|
| | | TY1353
|
| | | WM28
|
| |
GO_term
| GO:0015992
| IEA
| Inferred_automatically |
| | | GO:0016020
| IEA
| Inferred_automatically |
| | Contained_in_operon | CEOP3556
|
| |
Structured_description
|
Provisional_description
| unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons. | Paper_evidence | WBPaper00004601
|
| | | | | Person_evidence | WBPerson1843
|
| | | | | Curator_confirmed | WBPerson1843
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | unc-32 is one of four C. elegans genes encoding V-ATPase a subunits along with vha-5, vha-6, and vha-7. |
| | | | Each of these genes generally demonstrates tissue-specific, nonoverlapping expression. |
| | | Concise_description | unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons. |
|
Molecular_info (6)
|
|
Experimental_info
|
RNAi_result (6)
|
| |
WB_RNAi_result (8)
|
| |
Expr_pattern
| Expr21
|
| | | Expr848
|
| | | Expr849
|
| | | Expr2405
|
|
Reference (109)
|
| Method | Gene
|