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Gene: ZK637.8   

ZK637.8SMapS_parentSequenceZK637
ChromosomeIII
Identity (5)
Gene_info Gene_classunc
Reference_allelee189
Allele (5)
Phenotype e189 : severe coiler little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c. ES3 ME0 NA1 (rare mutation).
[Thierry-Mieg]
See also eIs16, f120, f121, f123
[C.elegansII] e189 : severe coiler, little movement in adult; moves well in L1 but coils in response to touch in L2 and later stages; rather small and thin; weakly Egl-c; Ric. ES3 ME0. OA>5: f123 (lethal, f123/e189 coiler),f121 (lethal, f121/e189 almost WT), ut61, ut111(embryonic lethals, irregular shape). Most alleles lethal. Cloned: probably encodes protein with homology to glutathione reductase (ZK637.10); downstream gene in operon. [Brenner 1974; Nguyen et al. 1995; FF; JC]
Strain BA676
BB1
BC4142
BC4143
BC4144
BC4145
BC4148
BC4149
BC4151
BC4152
BC4153
BC4154
BC4155
BC4156
BC4157
BC4159
BC4163
BC4164
BC4165
BC4166
BC4167
BC4168
BC4171
BC4172
BC4173
BC4179
BC4181
BC4185
BC4186
BC4187
BC4188
BC4190
BC4192
BC4212
BC4213
BC4216
BC4218
BC4219
BC4222
BC4224
BC4225
BC4227
BC4229
BC4231
BC4233
BC4235
BC4237
BC4241
BC4242
BC4243
BC4245
BC4246
BC4247
BC4249
BC4253
BC4255
BC4256
BC4258
BC4259
BC4261
BC4262
BC4267
BC4270
BC4271
BC4634
BC4637
BC4638
BC4677
BC4696
BC4697
BC4799
BC4822
BC4823
BC4824
BC4825
BC4826
BC4827
BC4828
BC4829
BC4831
BC4832
BC4833
BC4834
BC4835
BC4836
BC4838
BC4841
BC4843
BC4844
BC4845
BC4846
BC4847
BC4848
BC4849
BC4850
BC4851
BC4852
BC4853
BC4854
BC4855
BC4856
BC4857
BC4858
BC4859
BC4860
BC4862
BC4863
BC4864
BC4865
BC4866
BC4867
BC4868
BC4869
BC4870
BC4873
BC4874
BC4875
BC4876
BC4878
BC4879
BC4880
BC4881
BC4882
BC4883
BC4997
BC5078
BS913
BW1369
CB189
CB1918
CB2195
CB2196
CB2206
CB4118
CH1180
CX2914
DA589
DG769
DG783
DG784
DG786
DG800
DG801
DG815
DR129
DR130
DR133
DR284
DR410
EH250
EL69
FF275
FF276
FF451
FF628
GE2244
GE1825
GE2167
GE2171
GE2172
GE2175
GE2180
GE2198
GE2199
GE2204
GE2211
GE2219
GE2238
GE2239
GE2240
GE2242
GE2245
GE2255
GE2259
GE2345
GE2349
GE2353
GE2358
GE2364
GE2533
GE2534
GE2576
GE2606
GE2614
GE2626
GE2628
GE2629
GE2633
GE2636
GE2638
GE2656
GE2659
GE2663
GE2685
GE2690
GE2720
GE2722
GE2723
GE2727
GE2730
GE2929
GE2935
GE2940
GE2941
GE2946
GE2948
GE2952
GE2959
GE2961
GE3023
GE3841
GS60
GS107
GS311
GS316
GS320
GS328
GS387
GS776
GS807
GS878
GS883
HY463
JK633
JK892
JK948
JK966
JK967
JK968
JK1122
JK1129
JK1505
LB128
MH37
MT465
MT688
MT706
MT1373
MT1422
MT1799
MT1908
MT1909
MT2343
MT2351
MT3022
MT3025
MT3751
MT4009
MT4500
MT4947
MT4979
MT4997
MT5000
NG2618
OH2638
OH2639
PJ1153
PJ1158
PS2943
RW1522
SP17
SP462
SP471
ST20
ST21
ST22
ST35
TY415
TY562
TY567
TY578
TY1353
WM28
GO_term GO:0015992 IEA Inferred_automatically
GO:0016020 IEA Inferred_automatically
Contained_in_operonCEOP3556
Structured_description Provisional_description unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.Paper_evidenceWBPaper00004601
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
unc-32 is one of four C. elegans genes encoding V-ATPase a subunits along with vha-5, vha-6, and vha-7.
Each of these genes generally demonstrates tissue-specific, nonoverlapping expression.
Concise_descriptionunc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.
Molecular_info (6)
Experimental_info RNAi_result (6)
WB_RNAi_result (8)
Expr_pattern Expr21
Expr848
Expr849
Expr2405
Reference (109)
MethodGene