RNAiDB Tree View

Gene: ZK856.1

ZK856.1	SMap	S_parent	Sequence	ZK856
	Chromosome	V
	Identity (5)
	Gene_info	Gene_class	cul
		GO_term	GO:0007049	IEA	Inferred_automatically
		Contained_in_operon	CEOP5246
		Structured_description	Provisional_description	cul-5 encodes a cullin, orthologous to vasopressin-activated calcium-mobilizing receptor-1 in mammals, that is thought to regulate the cell cycle by virtue of its paralogy to cul-1 and cul-2; however, CUL-5 is dispensable for viability and gross morphology in mass RNAi screens, and does not appear to interact with any of 17 Skp1-related proteins (SKR-1 through SKR-21).	Paper_evidence	WBPaper00002473
						WBPaper00005128
						WBPaper00005654
					Person_evidence	WBPerson567
					Curator_confirmed	WBPerson567
					Date_last_updated	17 Jun 2004 00:00:00
				Cullins fall into three families represented today by C. elegans genes CUL-1/2, CUL-3/4, and CUL-5, respectively.
				The first two protein groups underwent further duplication and divergence prior to the divergence of nematodes and vertebrates, so that five cullin families exist in worms and humans (orthologous to CUL-1 through CUL-5).
			Concise_description	cul-5 encodes a cullin, orthologous to vasopressin-activated calcium-mobilizing receptor-1 in mammals, that is thought to regulate the cell cycle by virtue of its paralogy to cul-1 and cul-2; however, CUL-5 is dispensable for viability and gross morphology in mass RNAi screens, and does not appear to interact with any of 17 Skp1-related proteins (SKR-1 through SKR-21).
	Molecular_info (5)
	Experimental_info	RNAi_result	Cenix:142-d12
			JA:ZK856.1
		WB_RNAi_result	JA:ZK856.1
			MV_SV:mv_ZK856.1
			Cenix:142-d12
		Expr_pattern	Expr6369
		Y2H_target	Y2H004133
	Reference	WBPaper00006054
		WBPaper00002473
		WBPaper00005736
	Method	Gene