RNAiDB Tree View

Gene: ZK858.4

ZK858.4	SMap	S_parent	Sequence	ZK858
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	mel
		Reference_allele	ct61
		Allele (7)
		Phenotype	[Mains PE] ct61sb4 is a recessive maternal-effect lethal.
			[C.elegansII] ct61dm,ts : dominant maternal effect lethal, at 25C most embryos from ct61/+ mothers have early cleavage defects, arrest prior to morphogenesis; at 15C impenetrant maternal effect Vab. More severe defects in progeny from homozygous mothers.OA1: revertant ct61sb4 is a recessive maternal-effect lethal. [Mains et al. 1990; HR]
			[Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C.
		Strain (5)
		GO_term	GO:0005515	IEA	Inferred_automatically
		Structured_description	Provisional_description	mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.	Paper_evidence	WBPaper00004129
						WBPaper00004589
						WBPaper00005262
						WBPaper00019282
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.
	Molecular_info (7)
	Experimental_info	RNAi_result	Cenix:81-d9
			JA:ZK858.4
			Simmer:ZK858.4:Screen_A
			Simmer:ZK858.4:Screen_B
		WB_RNAi_result (5)
		Gene_regulation	Trans_regulator	cgc6054_ned-8.a
		Y2H_bait (57)
		Y2H_target (13)
		Interaction (11)
	Reference (38)
	Remark	Sequence connection from email by PE Mains [krb 020719]
	Method	Gene