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Gene: ZK858.4   

ZK858.4SMapS_parentSequenceZK858
ChromosomeI
Identity (5)
Gene_info Gene_classmel
Reference_allelect61
Allele (7)
Phenotype [Mains PE] ct61sb4 is a recessive maternal-effect lethal.
[C.elegansII] ct61dm,ts : dominant maternal effect lethal, at 25C most embryos from ct61/+ mothers have early cleavage defects, arrest prior to morphogenesis; at 15C impenetrant maternal effect Vab. More severe defects in progeny from homozygous mothers.OA1: revertant ct61sb4 is a recessive maternal-effect lethal. [Mains et al. 1990; HR]
[Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C.
Strain (5)
GO_termGO:0005515 IEA Inferred_automatically
Structured_description Provisional_descriptionmel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis. Paper_evidence WBPaper00004129
WBPaper00004589
WBPaper00005262
WBPaper00019282
Person_evidenceWBPerson1843
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Concise_descriptionmel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.
Molecular_info (7)
Experimental_info (6)
Reference (38)
RemarkSequence connection from email by PE Mains [krb 020719]
MethodGene