RNAiDB Tree View

Gene: ZK858.4

ZK858.4	SMap	S_parent	Sequence	ZK858
	Chromosome	I
	Identity (5)
	Gene_info	Gene_class	mel
		Reference_allele	ct61
		Allele (7)
		Phenotype	[Mains PE] ct61sb4 is a recessive maternal-effect lethal.
			[C.elegansII] ct61dm,ts : dominant maternal effect lethal, at 25C most embryos from ct61/+ mothers have early cleavage defects, arrest prior to morphogenesis; at 15C impenetrant maternal effect Vab. More severe defects in progeny from homozygous mothers.OA1: revertant ct61sb4 is a recessive maternal-effect lethal. [Mains et al. 1990; HR]
			[Bowerman BA] temperature-sensitive embryonic lethal, permissive = 15 C, restrictive = 25 C.
		Strain (5)
		GO_term	GO:0005515	IEA	Inferred_automatically
		Structured_description	Provisional_description	mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.	Paper_evidence	WBPaper00004129
						WBPaper00004589
						WBPaper00005262
						WBPaper00019282
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis.
	Molecular_info (7)
	Experimental_info (6)
	Reference	WBPaper00004129
		WBPaper00003178
		WBPaper00001721
		WBPaper00001353
		WBPaper00014286
		WBPaper00020794
		WBPaper00006054
		WBPaper00023373
		WBPaper00014441
		WBPaper00006311
		WBPaper00014910
		WBPaper00017396
		WBPaper00001274
		WBPaper00001454
		WBPaper00001654
		WBPaper00001725
		WBPaper00001884
		WBPaper00001977
		WBPaper00002958
		WBPaper00004402
		WBPaper00005262
		WBPaper00006085
		WBPaper00006352
		WBPaper00016965
		WBPaper00017263
		WBPaper00018046
		WBPaper00018880
		WBPaper00019271
		WBPaper00019315
		WBPaper00022011
		WBPaper00022246
		WBPaper00006055
		WBPaper00006175
		WBPaper00024507
		WBPaper00024118
		WBPaper00025684
		WBPaper00026065
		WBPaper00026118
	Remark	Sequence connection from email by PE Mains [krb 020719]
	Method	Gene