Gene: ZK858.4
ZK858.4 | SMap | S_parent | Sequence | ZK858 | ||
---|---|---|---|---|---|---|
Chromosome | I | |||||
Identity (5) | ||||||
Gene_info | Gene_class | mel | ||||
Reference_allele | ct61 | |||||
Allele (7) | ||||||
Phenotype (3) | ||||||
Strain (5) | ||||||
GO_term | GO:0005515 | IEA | Inferred_automatically | |||
Structured_description | Provisional_description | mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis. | Paper_evidence | WBPaper00004129 | ||
WBPaper00004589 | ||||||
WBPaper00005262 | ||||||
WBPaper00019282 | ||||||
Person_evidence | WBPerson1843 | |||||
Curator_confirmed | WBPerson1843 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | mel-26 encodes a MATH and BTB/POZ domain-containing protein that functions as a novel substrate-specific adaptor of the CUL-3-containing E3 ubiquitin ligase; MEL-26 is required maternally for formation of mitotic spindles in the early embryo, and as a component of a ubiquitin ligase complex, for degradation of the microtubule-severing protein MEI-1 at the meiosis to mitosis transition; MEL-26 is also required maternally for embryonic morphogenesis; since MEL-26 contains a meprin-associated Traf homology (MATH) domain, it might be involved in apoptosis. | |||||
Molecular_info (7) | ||||||
Experimental_info (6) | ||||||
Reference (38) | ||||||
Remark | Sequence connection from email by PE Mains [krb 020719] | |||||
Method | Gene |