RNAiDB Tree View

Gene: ZK863.6

ZK863.6	SMap	S_parent	Sequence	ZK863
	Chromosome	V
	Identity (5)
	Gene_info	Gene_class	dpy
		Allele	y130
			y228	Inferred_automatically	From strain object: TY1936
		Phenotype	[Hsu DR] y130 maternal ts lethal to XX animals, as a result of X chromosome overexpression; fully penetrant at restrictive temperature. XO animals viable abnormal males: scrawny, slow-growing, mating defective. NA3 (y185, y186).
			[C.elegansII] y130 : maternal ts lethal to XX animals, as a result of X chromosome overexpression;fully penetrant at restrictive temperature (25C). XO animals viable abnormal males: scrawny, slow-growing, mating defective. OA1: y228am. Cloned: 0.6 kb transcript, encodes 123 aa novel protein; antibody staining indicates DPY-30 ubiquitous nuclear protein, present in both sexes. Upstream gene in operon with rnp-1. [Hsu and Meyer 1994; Hsu et al. 1995]
		Strain	PS2958
			TY1936
		GO_term (6)
		Contained_in_operon	CEOP5328
		Structured_description	Provisional_description	The dpy-30 gene encodes an essential nuclear protein required for hermaphrodite dosage compensation as well as normal male development; DPY-30 is expressed ubiquitously throughout development and can be detected in two different multiprotein complexes: the SDC complex involved in dosage compensation and a second complex containing NOX-1 (a WD repeat-containing protein) and ASH-2 (a trithorax-related protein) that is homologous to the yeast Set1p complex involved in epigenetic regulation of transcription.	Paper_evidence	WBPaper00001991
						WBPaper00017136
					Person_evidence	WBPerson1843
					Curator_confirmed	WBPerson1843
					Date_last_updated	17 Jun 2004 00:00:00
			Concise_description	The dpy-30 gene encodes an essential nuclear protein required for hermaphrodite dosage compensation as well as normal male development; DPY-30 is expressed ubiquitously throughout development and can be detected in two different multiprotein complexes: the SDC complex involved in dosage compensation and a second complex containing NOX-1 (a WD repeat-containing protein) and ASH-2 (a trithorax-related protein) that is homologous to the yeast Set1p complex involved in epigenetic regulation of transcription.
	Molecular_info (6)
	Experimental_info (5)
	Reference (47)
	Method	Gene