Ace View of B0218.3 | |||
B0218.3 Details | |||
Description | pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway. | ||
Homology Group (KOG) | Mitogen-activated protein kinase |
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GO Terms | innate immune response (GO:0045087) ; programmed cell death (GO:0012501) ; protein amino acid phosphorylation (GO:0006468) ; cellular_component unknown (GO:0008372) ; protein kinase activity (GO:0004672) | ||
Location | IV:8148375..8151122 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Cenix:83-a1 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:83-a1 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | 3/3 test with wildtype results. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Gene Plot of B0218.3 | |||