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Gene/ORF B0218.3 (pmk-1) Ace View of B0218.3
B0218.3 Details Help
Description  pmk-1 encodes a mitogen-activated protein kinase (MAPK), orthologous to human p38 MAPK (OMIM:600289), that is required for eliciting gonadal programmed cell death in response to Salmonella enterica infection; PMK-1 lies upstream of CED-9, a negative regulator of apoptosis, in the programmed cell death pathway.
Homology Group (KOG)  Mitogen-activated protein kinase
GO Terms  innate immune response (GO:0045087) ; programmed cell death (GO:0012501) ; protein amino acid phosphorylation (GO:0006468) ; cellular_component unknown (GO:0008372) ; protein kinase activity (GO:0004672)
Location   IV:8148375..8151122
RNAi Phenotypes
Postembryonic Esp ; Esp ; Esp ; Esp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:83-a1
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:83-a1 (PCR reagent)
Delivery Method  Injection
Remark  3/3 test with wildtype results.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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