ORF Card Page

Gene/ORF B0261.2 (let-363)

B0261.2 Details

Description

let-363 encodes, by alternative splicing, two large (>2600-residue) proteins with C-terminal similarity to phosphatidylinositol kinase (PIK); LET-363 proteins are orthologous to S. cerevisiae Tor1p and Tor2p and human FRAP1 (OMIM:601231, mammalian target of FKBP12-rapamycin); LET-363 proteins are required for progression through the L3 stage of larval development and are thought to generally stimulate translation of most or all mRNAs ('global translation'); LET-363 activity is also necessary for normal development and physiology of the intestine; LET-363 proteins are expressed ubiquitously, including a maternal contribution to the early embryo.

Homology Group (KOG)

DNA-dependent protein kinase

GO Terms

larval development (sensu Nematoda) (GO:0002119) ; regulation of translation (GO:0006445) ; phosphoinositide phosphorylation (GO:0046854) ; cytoplasm (GO:0005737) ; phosphatidylinositol 3-kinase activity (GO:0016303) ; binding (GO:0005488) ; phosphotransferase activity, alcohol group as acceptor (GO:0016773)

Location

I:5245346..5263827

RNAi Phenotypes