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Gene/ORF B0334.11 (ooc-3) Ace View of B0334.11
B0334.11 Details Help
Description  ooc-3 encodes a nematode-specific protein with a predicted signal sequence, four predicted transmembrane domains, and two putative PEST sequences; OOC-3 is probably localized to the endoplasmic reticulum (ER), and is maternally required for correct localization of PAR-2 and PAR-3 in the P1 blastomere of the two-cell stage embryo; specifically, OOC-3 is required for restricting PAR-3 to the anterior cortex of the P1 blastomere to assure PAR-2 localization at the posterior cortex; more generally, OOC-3 is required to establish asymmetrical anterior-posterior cortical domains and spindle orientation in P1.
GO Terms  establishment and/or maintenance of cell polarity (GO:0007163) ; mitotic spindle orientation (GO:0000132) ; asymmetric protein localization (GO:0008105) ; endoplasmic reticulum (GO:0005783) ; molecular_function unknown (GO:0005554)
Location   II:11492738..11495621
RNAi Phenotypes
Early_embryo Complex Phenotype
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:145-c8
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Complex Phenotype
RNAi Reagent Name & Type Cenix:145-c8 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Complex Phenotype
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:B0334.11
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_B0334.11 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
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