Ace View of B0336.8 | |
B0336.8 Details | |
Description | lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities. |
Homology Group (KOG) | Protein conjugation factor involved in autophagy |
GO Terms | autophagic vacuole formation (GO:0000045) ; cytoplasm (GO:0005737) |
Location | III:5697098..5698358 |
RNAi Phenotypes | No phenotypes observed. |
External Links | |
Associated RNAi Experiments | |
Cenix:230-c1 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:230-c1 (PCR reagent) |
Delivery Method | Injection |
Remark | Wildtype results in all three tests. |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Cenix:310-d5 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:310-d5 (PCR reagent) |
Delivery Method | Injection |
Remark | wild type |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Cenix:310-e10 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:310-e10 (PCR reagent) |
Delivery Method | Injection |
Remark | wild type |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
Cenix:329-c6 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | Cenix:329-c6 (PCR reagent) |
Delivery Method | Injection |
Remark | early embryonic: No significant defects. |
Laboratory | TH |
Date | 2005-3-24 |
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
JA:B0336.8 | |
Adult Phenotypes | WT |
RNAi Reagent Name & Type | sjj_B0336.8 (PCR reagent) |
Laboratory | JA |
Date | 2003-1-10 |
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." |
TH:310D5 | |
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
RNAi Reagent Name & Type | TH:310D5 (PCR reagent) |
Delivery Method | Injection |
Laboratory | TH |
Date | 2000-11-16 |
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
TH:310E10 | |
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
RNAi Reagent Name & Type | TH:310E10 (PCR reagent) |
Delivery Method | Injection |
Laboratory | TH |
Date | 2000-11-16 |
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
TH:329C6 | |
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
RNAi Reagent Name & Type | TH:329C6 (PCR reagent) |
Delivery Method | Injection |
Laboratory | TH |
Date | 2000-11-16 |
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." |
Gene Plot of B0336.8 | |