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Gene/ORF B0336.8 (lgg-3) Ace View of B0336.8
B0336.8 Details Help
Description  lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities.
Homology Group (KOG)  Protein conjugation factor involved in autophagy
GO Terms  autophagic vacuole formation (GO:0000045) ; cytoplasm (GO:0005737)
Location   III:5697098..5698358
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:B0336.8 WT
Cenix:310-d5 WT
Cenix:230-c1 WT
TH:329C6 WT
TH:310D5 WT
Cenix:329-c6 WT
Cenix:310-e10 WT
TH:310E10 WT
Gene Plot of B0336.8 Browse using GBrowse
Gene Map