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Gene/ORF B0348.6 (ife-3) Ace View of B0348.6
B0348.6 Details Help
Description  ife-3 encodes one of five C. elegans homologs of the mRNA cap-binding protein eIF4E; by homology, IFE-3 is predicted to bind capped mRNA and mediate its recruitment to ribosomes during translation initiation; in vitro, IFE-3 binds a monomethylated guanosine cap structure but does not bind a trimethylated guanosine cap, which suggests that IFE-3 likely mediates translation of those mRNAs that do not contain a spliced-leader sequence; of the C. elegans eIF4E isoforms, IFE-3 is the most similar to human eIF4E and is the only isoform required for viability (homozygous ife-3 mutant embryos arrest in the early division stages of embryogenesis); IFE-3 is enriched in the adult gonad.
GO Terms  RNA binding (GO:0003723) ; translation initiation factor activity (GO:0003743) ; translational initiation (GO:0006413) ; cytoplasm (GO:0005737)
Location   V:6017..8050
RNAi Phenotypes
Early_embryo Cortical Dynamics abnormal ; Severe Pleiotropic Defects
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:B0348.6 WT
Experiments with Non-Wild Phenotypes
Cenix:145-e8 Cortical Dynamics abnormal ; Emb
Cenix:30-d4 Emb ; Severe Pleiotropic Defects
Gene Plot of B0348.6 Browse using GBrowse
Gene Map