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Gene/ORF B0464.5 (spk-1) Ace View of B0464.5
B0464.5 Details Help
Description  spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600).
Homology Group (KOG)  Serine/threonine protein kinase
Location   III:9456059..9463283
RNAi Phenotypes
Early_embryo Cyk
Larva Let
Adult Pvl ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:320-d1
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Cyk
RNAi Reagent Name & Type Cenix:320-d1 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Cytokinesis
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
TH:341-f8
RNAi Reagent Name & Type TH:341-f8 (PCR reagent)
Gene Plot of B0464.5 Browse using GBrowse
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