Gene/ORF
B0464.5 (spk-1)
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Ace View of B0464.5
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B0464.5 Details |
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Description |
spk-1 encodes a serine/threonine kinase orthologous to the highly conserved serine/arginine-rich protein kinases (SRPKs) that phosphorylate SR proteins, essential components of the pre-mRNA splicing machinery; SPK-1, required for embryogenesis and germline development, can directly bind and phosphorylate RSP-3 (CeSF2/ASF), an SR splicing factor homolog; SPK-1 is expressed predominantly in the adult germline; SPK-1 is homologous to human RSK2, which when mutated leads to Coffin-Lowry syndrome (OMIM:303600). |
Homology Group (KOG) |
Serine/threonine protein kinase
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Location |
III:9456059..9463283 |
RNAi Phenotypes |
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External Links |
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Associated RNAi Experiments |
View Details
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Cenix:320-d1
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Embryonic Phenotypes |
Emb Penetrance None reported |
Adult Phenotypes |
Cyk
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RNAi Reagent Name & Type |
Cenix:320-d1 (PCR reagent) |
Delivery Method |
Injection |
Remark |
early embryonic: Cytokinesis |
Laboratory |
TH |
Date |
2005-3-24 |
Reference |
Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." |
TH:341-f8
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RNAi Reagent Name & Type |
TH:341-f8 (PCR reagent) |
Gene Plot of B0464.5 |
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