Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
Link to B0464.7.1Link to B0464.7.2Link to B0464.8RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Gene/ORF B0464.7 (baf-1) Ace View of B0464.7
B0464.7 Details Help
Description  baf-1 encodes a small, novel protein that is highly conserved amongst metazoa; BAF-1 binds double-stranded DNA nonspecifically in vitro and is essential for proper chromosome segregation, embryogenesis, and gonad development in vivo; biochemical and phenotypic analyses suggest that BAF-1 functions as an intramolecular bridge that mediates nuclear assembly and chromatin capture by the reforming nuclear envelope; by homology with mammalian BAF proteins, BAF-1 is also predicted to play a role in regulating gene expression and higher-order chromatin structure; during interphase, BAF-1 colocalizes with LMN-1/lamin to the nuclear envelope and nuclear interior; during mitosis, BAF-1 is present in a more punctate pattern, localizing near condensing chromatin and maintaining this localization through telophase; BAF-1 localization during nuclear assembly requires the activity of LMN-1/lamin, EMR-1/emerin, and LEM-2/MAN1.
Homology Group (KOG)  DNA-bridging protein BAF
GO Terms  embryonic development (sensu Animalia) (GO:0009792) ; chromosome segregation (GO:0007059) ; chromosome organization and biogenesis (GO:0051276) ; double-stranded DNA binding (GO:0003690) ; protein self binding (GO:0042802) ; DNA binding (GO:0003677)
Location   III:9466965..9468414
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
Adult Bmd ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:173-g2 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No signficant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Gene Plot of B0464.7 Browse using GBrowse
Gene Map