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Gene/ORF B0547.1 (csn-5) Ace View of B0547.1
B0547.1 Details Help
Description  csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.
Homology Group (KOG)  COP9 signalosome, subunit CSN5
Location   IV:5649116..5651441
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:B0547.1 Emb
JA:B0547.1 Emb
Cenix:39-b7 Emb ; WT_postembryonic_morphology
Gene Plot of B0547.1 Browse using GBrowse
Gene Map