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Gene/ORF B0547.1 (csn-5) Ace View of B0547.1
B0547.1 Details Help
Description  csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4.
Homology Group (KOG)  COP9 signalosome, subunit CSN5
Location   IV:5649116..5651441
RNAi Phenotypes
Postembryonic WT_postembryonic_morphology
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
JA:B0547.1
Embryonic Phenotypes  Emb Penetrance 80 %
RNAi Reagent Name & Type sjj_B0547.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:B0547.1
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
RNAi Reagent Name & Type sjj_B0547.1 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Cenix:39-b7
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  WT_postembryonic_morphology
RNAi Reagent Name & Type Cenix:39-b7 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects observed.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
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