Ace View of B0547.1 | |||
B0547.1 Details | |||
Description | csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. | ||
Homology Group (KOG) | COP9 signalosome, subunit CSN5 |
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Location | IV:5649116..5651441 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
JA:B0547.1 | |||
Embryonic Phenotypes | Emb Penetrance 80 % | ||
RNAi Reagent Name & Type | sjj_B0547.1 (PCR reagent) | ||
Laboratory | JA | ||
Date | 2003-1-10 | ||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||
Simmer:B0547.1 | |||
Embryonic Phenotypes | Emb Penetrance 50 - 80 % | ||
RNAi Reagent Name & Type | sjj_B0547.1 (PCR reagent) | ||
Laboratory | NL | ||
Date | 2003-10-01 | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Cenix:39-b7 | |||
Embryonic Phenotypes | Emb Penetrance None reported | ||
Adult Phenotypes | WT_postembryonic_morphology |
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RNAi Reagent Name & Type | Cenix:39-b7 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | early embryonic: No significant defects observed. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
Gene Plot of B0547.1 | |||