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Gene/ORF C02F5.1 (knl-1) Ace View of C02F5.1
C02F5.1 Details Help
Description  knl-1 encodes a novel acidic protein with a coiled-coil region at its C-terminus; KNL-1 is an essential kinetochore component that is required for proper spindle elongation and chromosome separation, and in the kinetochore assembly pathway, plays a key role in linking the initiation of kinetochore formation with the construction of a functional microtubule-binding interface; in the assembly pathway, KNL-1 functions downstream of the DNA-proximal kinetochore components CeCENP-A/HCP-3 and CeCENP-B/HCP-4 and upstream of the outer kinetochore components HIM-10/Nuf2p, NDC-80/HEC1, CeBUB-1, HCP-1, and CeCLASP2/CLS-2; in expression studies in the one-cell embryo, KNL-1 localizes to kinetochores throughout mitosis.
Location   III:8250151..8254258
RNAi Phenotypes
Early_embryo Sister Chromatid Separation abnormal (Cross-eyed) ; Chromosome Segregation (karyomeres) abnormal ; Multiple nuclei
Adult Pvl ; Pvl ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
Simmer:C02F5.1 Emb
TH:307C1 Emb
JA:C02F5.1 Emb ; Pvl
Cenix:307-c1 Emb ; Sister Chromatid Separation abnormal (Cross-eyed)
Cenix:312-f4 Chromosome Segregation (karyomeres) abnormal ; Emb
Gene Plot of C02F5.1 Browse using GBrowse
Gene Map