Ace View of C05D11.3 | |||||||
C05D11.3 Details | |||||||
Description | C05D11.3 encodes an ortholog of APACD (ATP binding protein associated with cell differentiation) conserved in eukaryotes; C05D11.3 has a thioredoxin-like domain, probably lacking catalytic activity; mouse APACD is both cytoplasmic and nuclear, often localized to centrosomes and midbody; C05D11.3 is expressed in all developmental stages, preferentially in neurons and vulva; C05D11.3 is required for normal mitotic spindle formation, pronuclear migration and nuclear-centrosome rotation. | ||||||
Homology Group (KOG) | ATP binding protein |
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GO Terms | electron transporter activity (GO:0005489) ; electron transport (GO:0006118) | ||||||
Location | III:6431718..6433315 | ||||||
RNAi Phenotypes |
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External Links | |||||||
Associated RNAi Experiments | |||||||
Cenix:306-c12 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
Adult Phenotypes | Pnm |
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RNAi Reagent Name & Type | Cenix:306-c12 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | early embryonic: Pronuclear Migration | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
Cenix:340-h12 | |||||||
Adult Phenotypes | Sterile F0/Fertility Problems |
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RNAi Reagent Name & Type | Cenix:340-h12 (PCR reagent) | ||||||
Delivery Method | Injection | ||||||
Remark | post-embryonic: Sterile F0/Fertility Problems | ||||||
Laboratory | TH | ||||||
Date | 2005-3-24 | ||||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||
JA:C05D11.3 | |||||||
Embryonic Phenotypes | Emb Penetrance 100 % | ||||||
Adult Phenotypes | Egl Unc |
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RNAi Reagent Name & Type | sjj_C05D11.3 (PCR reagent) | ||||||
Laboratory | JA | ||||||
Date | 2003-1-10 | ||||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||||
Simmer:C05D11.3 | |||||||
Embryonic Phenotypes | Emb Penetrance 50 - 80 % | ||||||
Adult Phenotypes | Pvl Unc |
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RNAi Reagent Name & Type | sjj_C05D11.3 (PCR reagent) | ||||||
Laboratory | NL | ||||||
Date | 2003-10-01 | ||||||
Strain | NL4256 rrf-3(pk1426) | ||||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||
TH:306c12 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
RNAi Reagent Name & Type | TH:306c12 (PCR reagent) | ||||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (C05D11.3-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal). | ||||||
Laboratory | TH | ||||||
Date | 2000-11-16 | ||||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||||
TH:340h12 | |||||||
Embryonic Phenotypes | Emb Penetrance None reported | ||||||
RNAi Reagent Name & Type | TH:340h12 (PCR reagent) | ||||||
Remark | Phenotype comment -- Confirmed with independent dsRNA (C05D11.3-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal). | ||||||
Laboratory | TH | ||||||
Date | 2000-11-16 | ||||||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||||||
Gene Plot of C05D11.3 | |||||||