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Gene/ORF C05D11.3 Ace View of C05D11.3
C05D11.3 Details Help
Description  C05D11.3 encodes an ortholog of APACD (ATP binding protein associated with cell differentiation) conserved in eukaryotes; C05D11.3 has a thioredoxin-like domain, probably lacking catalytic activity; mouse APACD is both cytoplasmic and nuclear, often localized to centrosomes and midbody; C05D11.3 is expressed in all developmental stages, preferentially in neurons and vulva; C05D11.3 is required for normal mitotic spindle formation, pronuclear migration and nuclear-centrosome rotation.
Homology Group (KOG)  ATP binding protein
GO Terms  electron transporter activity (GO:0005489) ; electron transport (GO:0006118)
Location   III:6431718..6433315
RNAi Phenotypes
Early_embryo Pnm
Postembryonic Bli
Adult Egl ; Pvl ; Pvl ; Sterile F0/Fertility Problems ; Unc ; Unc
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:306-c12
Embryonic Phenotypes  Emb Penetrance None reported
Adult Phenotypes  Pnm
RNAi Reagent Name & Type Cenix:306-c12 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Pronuclear Migration
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Cenix:340-h12
Adult Phenotypes  Sterile F0/Fertility Problems
RNAi Reagent Name & Type Cenix:340-h12 (PCR reagent)
Delivery Method  Injection
Remark  post-embryonic: Sterile F0/Fertility Problems
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C05D11.3
Embryonic Phenotypes  Emb Penetrance 100 %
Adult Phenotypes  Egl
Unc
RNAi Reagent Name & Type sjj_C05D11.3 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:C05D11.3
Embryonic Phenotypes  Emb Penetrance 50 - 80 %
Adult Phenotypes  Pvl
Unc
RNAi Reagent Name & Type sjj_C05D11.3 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
TH:306c12
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:306c12 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (C05D11.3-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
TH:340h12
Embryonic Phenotypes  Emb Penetrance None reported
RNAi Reagent Name & Type TH:340h12 (PCR reagent)
Remark  Phenotype comment -- Confirmed with independent dsRNA (C05D11.3-RNA2; similar DIC phenotype, but progeny test was not embryonic lethal).
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
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