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Gene/ORF C05D11.6 (nas-4) Ace View of C05D11.6
C05D11.6 Details Help
Description  nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut.
Homology Group (KOG)  Meprin A metalloprotease
GO Terms  metallopeptidase activity (GO:0008237) ; zinc ion binding (GO:0008270) ; proteolysis and peptidolysis (GO:0006508) ; astacin activity (GO:0008533)
Location   III:6411136..6415329
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:C05D11.6 WT
Cenix:304-a8 WT
TH:306B9 WT
TH:304A8 WT
Cenix:306-b9 WT
Gene Plot of C05D11.6 Browse using GBrowse
Gene Map