Ace View of C07H6.6 | |||
C07H6.6 Details | |||
Description | The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues. | ||
Homology Group (KOG) | Uncharacterized conserved protein |
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GO Terms | determination of adult life span (GO:0008340) ; telomere maintenance (GO:0000723) ; DNA damage response, signal transduction resulting in cell cycle arrest (GO:0000077) ; embryonic development (GO:0009790) ; cytoplasm (GO:0005737) ; molecular_function unknown (GO:0005554) | ||
Location | III:7514742..7518843 | ||
RNAi Phenotypes |
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External Links | |||
Associated RNAi Experiments | |||
Cenix:305-c5 | |||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:305-c5 (PCR reagent) | ||
Delivery Method | Injection | ||
Remark | early embryonic: No significant defects. | ||
Laboratory | TH | ||
Date | 2005-3-24 | ||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||
TH:305C5 | |||
Adult Phenotypes | WTDIC phenotype -- Embryonic development normal |
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RNAi Reagent Name & Type | TH:305C5 (PCR reagent) | ||
Delivery Method | Injection | ||
Laboratory | TH | ||
Date | 2000-11-16 | ||
Reference | Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...." | ||
Gene Plot of C07H6.6 | |||