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Gene/ORF C07H6.6 (clk-2) Ace View of C07H6.6
C07H6.6 Details Help
Description  The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues.
Homology Group (KOG)  Uncharacterized conserved protein
GO Terms  determination of adult life span (GO:0008340) ; telomere maintenance (GO:0000723) ; DNA damage response, signal transduction resulting in cell cycle arrest (GO:0000077) ; embryonic development (GO:0009790) ; cytoplasm (GO:0005737) ; molecular_function unknown (GO:0005554)
Location   III:7514742..7518843
RNAi Phenotypes
Adult Sck ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Cenix:305-c5
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:305-c5 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: No significant defects.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
TH:305C5
Adult Phenotypes  WTDIC phenotype -- Embryonic development normal
RNAi Reagent Name & Type TH:305C5 (PCR reagent)
Delivery Method  Injection
Laboratory  TH
Date  2000-11-16
Reference  Gonczy P et al. (2000) Nature "Functional genomic analysis of cell division in C. elegans using RNAi of genes on ...."
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