| Ace View of C08B6.9 | |||||||||
| C08B6.9 Details | |||||||||
| Description | aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. | ||||||||
| Homology Group (KOG) | SMT3/SUMO-activating complex, AOS1/RAD31 component |
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| GO Terms | catalytic activity (GO:0003824) | ||||||||
| Location | V:10129707..10133277 | ||||||||
| RNAi Phenotypes |
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| External Links |    |
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| Associated RNAi Experiments | |||||||||
| PF:GL1_4E4 | |||||||||
| Embryonic Phenotypes | Emb Penetrance 80 - 100 % Sle | ||||||||
| Larval Phenotypes | Lva
Observed in >=10% of progeny. |
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| Adult Phenotypes | Abnormal size of pronucleus Multiple cavities P0 spindle does not rotate P0 spindle positioning defect |
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| RNAi Reagent Name & Type | sjj_C08B6.9 (PCR reagent) | ||||||||
| Delivery Method | Injection | ||||||||
| Remark | PCR product contains flanking T7 promoter sequences | ||||||||
| Laboratory | KK | ||||||||
| Date | 2002-11-19 | ||||||||
| Reference | Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" | Movies/Stacks/Images |  |
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| Cenix:13-h12 | |||||||||
| Embryonic Phenotypes | Emb Penetrance None reported | ||||||||
| Adult Phenotypes | WT_postembryonic_morphology |
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| RNAi Reagent Name & Type | Cenix:13-h12 (PCR reagent) | ||||||||
| Delivery Method | Injection | ||||||||
| Remark | early embryonic: Overall wildtype. | ||||||||
| Laboratory | TH | ||||||||
| Date | 2005-3-24 | ||||||||
| Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||||||
| Gene Plot of C08B6.9 | |||||||||
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