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Gene/ORF C09D8.1 (ptp-3) Ace View of C09D8.1
C09D8.1 Details Help
Description  ptp-3 encodes a receptor-like tyrosine phosphatase orthologous to the LAR (Leukocyte Common Antigen Related, OMIM:179590) subfamily of receptor-like tyrosine phosphatases that contain extracellular immunoglobulin-like and fibronectin type III domains and have been implicated in linking cell adhesion to intracellular phosphotyrosine levels; PTP-3 plays a role in gastrulation and epidermal development and functions partly redundantly with the VAB-1 Eph receptor and ephrins VAB-2 and EFN-4 to regulate embryonic morphogenesis; PTP-3 is expressed in many tissues during early embryogenesis, but expression later becomes localized to neuronal processes and epithelial adherens junctions.
GO Terms  gastrulation (GO:0007369) ; epidermal differentiation (GO:0008544) ; synaptogenesis (GO:0007416) ; protein amino acid dephosphorylation (GO:0006470) ; adherens junction (GO:0005912) ; transmembrane receptor protein tyrosine phosphatase activity (GO:0005001) ; protein phosphatase activity (GO:0004721) ; protein tyrosine phosphatase activity (GO:0004725)
Location   II:10975052..11012554
RNAi Phenotypes
Postembryonic Morphology defect
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:201-c1
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:201-c1 (PCR reagent)
Delivery Method  Injection
Remark  early embryonic: Overall wildtype. Subtle defects in the range of normal variability observed.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C09D8.1
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C09D8.1 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
JA:C09D8.2
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C09D8.2 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Gene Plot of C09D8.1 Browse using GBrowse
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