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Gene/ORF C09H6.2 (lin-10) Ace View of C09H6.2
C09H6.2 Details Help
Description  The lin-10 gene encodes a PDZ and PTB domain-containing protein that is homologous to mammalian Munc interacting proteins (Mint1, OMIM:602414) and is required for polarized protein localization; LIN-10 is required for proper localization of the LET-23 EGF receptor to the basolateral membrane of the vulval precursor cells and for proper postsynaptic localization of GLR-1, an AMPA-type glutamate receptor in interneurons; LIN-10 is detected in the cytoplasm, membrane, and at particularly high levels in the Golgi.
Homology Group (KOG)  Beta amyloid precursor-binding protein
PDZ domain
GO Terms  asymmetric protein localization (GO:0008105) ; nerve-nerve synaptic transmission (GO:0007270) ; positive regulation of vulval development (sensu Nematoda) (GO:0040026) ; sensory perception of touch (GO:0050975) ; receptor clustering (GO:0043113) ; cytoplasm (GO:0005737) ; plasma membrane (GO:0005886) ; Golgi trans cisterna (GO:0000138) ; neuron projection (GO:0043005) ; cell soma (GO:0043025) ; trans-Golgi network transport vesicle (GO:0030140) ; phosphotyrosine binding (GO:0001784) ; protein binding (GO:0005515)
Location   I:8109339..8119707
RNAi Phenotypes No phenotypes observed.
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:71-e2 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wt
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
Adult Phenotypes  WT
RNAi Reagent Name & Type sjj_C09H6.2 (PCR reagent)
Laboratory  JA
Date  2000-11-16
Reference  Fraser AG et al. (2000) Nature "Functional genomic analysis of C. elegans chromosome I by systematic RNA ...."
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