ORF Card Page

Gene/ORF C10H11.9 (let-502)

C10H11.9 Details

Description

let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization.

Homology Group (KOG)

Rho-associated, coiled-coil containing protein kinase

GO Terms

embryonic development (GO:0009790) ; regulation of cell shape (GO:0008360) ; Rho protein signal transduction (GO:0007266) ; protein amino acid phosphorylation (GO:0006468) ; nucleus (GO:0005634) ; protein serine/threonine kinase activity (GO:0004674) ; ATP binding (GO:0005524) ; intracellular signaling cascade (GO:0007242) ; protein kinase activity (GO:0004672)

Location

I:4737771..4744710

RNAi Phenotypes