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Gene/ORF C12C8.3 (lin-41) Ace View of C12C8.3
C12C8.3 Details Help
Description  The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.
Homology Group (KOG)  Predicted E3 ubiquitin ligase
GO Terms  regulation of development, heterochronic (GO:0040034) ; regulation of epidermal cell differentiation (GO:0045604) ; gametogenesis (GO:0007276) ; negative regulation of translation (GO:0016478) ; cytoplasm (GO:0005737) ; protein binding (GO:0005515) ; intracellular (GO:0005622) ; copper ion binding (GO:0005507) ; zinc ion binding (GO:0008270) ; ubiquitin-protein ligase activity (GO:0004842) ; protein ubiquitination (GO:0016567) ; ubiquitin ligase complex (GO:0000151)
Location   I:9334393..9342886
RNAi Phenotypes
Postembryonic Adl
Adult Dpy ; Rup ; Unc ; Ste ; Ste ; Sma ; Sma ; Sterility/Impaired Fertility in F0 ; Sck ; Sterile F0/Fertility Problems ; Stp
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
JA:C12C8.3 WT
Experiments with Non-Wild Phenotypes
Cenix:137-e7 Sterile F0/Fertility Problems ; Sterility/Impaired Fertility in F0
Simmer:C12C8.3:Screen_B Adl ; Rup ; Sma ; Ste ; Stp
Simmer:C12C8.3:Screen_A Dpy ; Sck ; Sma ; Ste ; Unc
Gene Plot of C12C8.3 Browse using GBrowse
Gene Map