Ace View of C14A4.4 | |||||
C14A4.4 Details | |||||
Description | crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. | ||||
GO Terms | nucleic acid binding (GO:0003676) ; 3'-5' exonuclease activity (GO:0008408) ; intracellular (GO:0005622) | ||||
Location | II:10587555..10592958 | ||||
RNAi Phenotypes |
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External Links | |||||
Associated RNAi Experiments | |||||
Cenix:201-f1 | |||||
Adult Phenotypes | WT |
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RNAi Reagent Name & Type | Cenix:201-f1 (PCR reagent) | ||||
Delivery Method | Injection | ||||
Remark | 3/3 tests are wildtype. | ||||
Laboratory | TH | ||||
Date | 2005-3-24 | ||||
Reference | Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...." | ||||
JA:C14A4.4 | |||||
Larval Phenotypes | Gro |
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Adult Phenotypes | Pch |
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RNAi Reagent Name & Type | sjj_C14A4.4 (PCR reagent) | ||||
Laboratory | JA | ||||
Date | 2003-1-10 | ||||
Reference | Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...." | ||||
Simmer:C14A4.4 | |||||
Larval Phenotypes | Lva |
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RNAi Reagent Name & Type | sjj_C14A4.4 (PCR reagent) | ||||
Laboratory | NL | ||||
Date | 2003-10-01 | ||||
Strain | NL4256 rrf-3(pk1426) | ||||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||
Gene Plot of C14A4.4 | |||||