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Gene/ORF C14A4.4 (crn-3) Ace View of C14A4.4
C14A4.4 Details Help
Description  crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
GO Terms  nucleic acid binding (GO:0003676) ; 3'-5' exonuclease activity (GO:0008408) ; intracellular (GO:0005622)
Location   II:10587555..10592958
RNAi Phenotypes
Postembryonic Pch ; Pch
Larva Lva ; Lva ; Gro ; Gro
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Summary
Cenix:201-f1
Adult Phenotypes  WT
RNAi Reagent Name & Type Cenix:201-f1 (PCR reagent)
Delivery Method  Injection
Remark  3/3 tests are wildtype.
Laboratory  TH
Date  2005-3-24
Reference  Sonnichsen B et al. (2005) Nature "Full-genome RNAi profiling of early embryogenesis in Caenorhabditis ...."
JA:C14A4.4
Larval Phenotypes  Gro
Adult Phenotypes  Pch
RNAi Reagent Name & Type sjj_C14A4.4 (PCR reagent)
Laboratory  JA
Date  2003-1-10
Reference  Kamath RS et al. (2003) Nature "Systemic functional analysis of the Caenorhabditis elegans genome using ...."
Simmer:C14A4.4
Larval Phenotypes  Lva
RNAi Reagent Name & Type sjj_C14A4.4 (PCR reagent)
Laboratory  NL
Date  2003-10-01
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Gene Plot of C14A4.4 Browse using GBrowse
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