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Gene/ORF C14A4.4 (crn-3) Ace View of C14A4.4
C14A4.4 Details Help
Description  crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial.
GO Terms  nucleic acid binding (GO:0003676) ; 3'-5' exonuclease activity (GO:0008408) ; intracellular (GO:0005622)
Location   II:10587555..10592958
RNAi Phenotypes
Postembryonic Pch ; Pch
Larva Lva ; Lva ; Gro ; Gro
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Wild Type RNAi Experiments
Cenix:201-f1 WT
Experiments with Non-Wild Phenotypes
JA:C14A4.4 Gro ; Pch
Simmer:C14A4.4 Lva
Gene Plot of C14A4.4 Browse using GBrowse
Gene Map