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Gene/ORF C14B9.4 (plk-1) Ace View of C14B9.4
C14B9.4 Details Help
Description  plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; PLK-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis, and additionally, may play a role in germline development; PLK-1 is proposed to phosphorylate REC-8, a meiotic-specific cohesin, thus promoting REC-8 degradation and subsequent separation of sister chromatids; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to centrosomes, metaphase chromatin, and during telophase, to the area between dividing chromatin.
GO Terms  regulation of cell cycle (GO:0000074) ; meiotic chromosome segregation (GO:0045132) ; polar body extrusion after meiotic divisions (GO:0040038) ; mitotic nuclear envelope breakdown (GO:0007077) ; centrosome (GO:0005813) ; protein serine/threonine kinase activity (GO:0004674) ; protein binding (GO:0005515) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468)
Location   III:8100869..8104397
RNAi Phenotypes
Early_embryo Slow cell cycle ; Slow cell cycle ; Complex Phenotype ; Osmotic Integrity defective ; Catastrophic one-cell arrest ; Catastrophic one-cell arrest ; Osmotically/ pressure sensitive ; Osmotically/ pressure sensitive ; Multiple nuclei in 1, 2, or 4-cell embryos
Postembryonic Adl ; Adl
Larva Lvl ; Lvl
Adult Reduced fecundity of injected worm ; Reduced fecundity of injected worm ; Pvl ; Pvl ; Pvl ; Ste ; Ste ; Ste
External Links  wormbase.org NCBI.org NBrowse
Associated RNAi Experiments View Details
Experiments with Non-Wild Phenotypes
PF:GL1_5C1 Catastrophic one-cell arrest ; Emb ; Osmotically/ pressure sensitive ; Slow cell cycle ; Ste ; Reduced fecundity of injected worm
Cenix:302-e10 Emb ; Osmotic Integrity defective
JA:K06H7.1 Adl ; Emb ; Lvl ; Pvl
JA:C14B9.4 Adl ; Emb ; Lvl ; Pvl
Simmer:K06H7.1 Emb
PF:GL1_4E6 Catastrophic one-cell arrest ; Emb ; Multiple nuclei in 1, 2, or 4-cell embryos ; Osmotically/ pressure sensitive ; Slow cell cycle ; Ste ; Reduced fecundity of injected worm
Cenix:302-f10 Complex Phenotype ; Emb
Simmer:C14B9.4 Emb
TH:302e10 Emb
TH:302f10 Emb
Gene Plot of C14B9.4 Browse using GBrowse
Gene Map