Ace View of C14B9.4 | |
C14B9.4 Details | |
Description | plk-1 encodes a serine/threonine polo-like kinase homologous to Drosophila polo and Saccharomyces cerevisiae CDC5; PLK-1 is required for meiotic nuclear envelope breakdown, polar body formation and extrusion, and proper chromosome segregation during meiosis, and additionally, may play a role in germline development; PLK-1 is proposed to phosphorylate REC-8, a meiotic-specific cohesin, thus promoting REC-8 degradation and subsequent separation of sister chromatids; PLK-1 is localized diffusely in the cytoplasm of mature oocytes, but during meiosis I becomes associated with pre-metaphase chromatin and then at anaphase with chromatin and the area between dividing chromatin; in embryos, PLK-1 localizes to centrosomes, metaphase chromatin, and during telophase, to the area between dividing chromatin. |
GO Terms | regulation of cell cycle (GO:0000074) ; meiotic chromosome segregation (GO:0045132) ; polar body extrusion after meiotic divisions (GO:0040038) ; mitotic nuclear envelope breakdown (GO:0007077) ; centrosome (GO:0005813) ; protein serine/threonine kinase activity (GO:0004674) ; protein binding (GO:0005515) ; protein kinase activity (GO:0004672) ; ATP binding (GO:0005524) ; protein amino acid phosphorylation (GO:0006468) |
Location | III:8100869..8104397 |
RNAi Phenotypes | |
External Links | |
Associated RNAi Experiments | |
Experiments with Non-Wild Phenotypes | |
PF:GL1_5C1 | Catastrophic one-cell arrest ; Emb ; Osmotically/ pressure sensitive ; Slow cell cycle ; Ste ; Reduced fecundity of injected worm |
Cenix:302-e10 | Emb ; Osmotic Integrity defective |
JA:K06H7.1 | Adl ; Emb ; Lvl ; Pvl |
JA:C14B9.4 | Adl ; Emb ; Lvl ; Pvl |
Simmer:K06H7.1 | Emb |
PF:GL1_4E6 | Catastrophic one-cell arrest ; Emb ; Multiple nuclei in 1, 2, or 4-cell embryos ; Osmotically/ pressure sensitive ; Slow cell cycle ; Ste ; Reduced fecundity of injected worm |
Cenix:302-f10 | Complex Phenotype ; Emb |
Simmer:C14B9.4 | Emb |
TH:302e10 | Emb |
TH:302f10 | Emb |
Gene Plot of C14B9.4 | |